Adiponectin is plasma adipokin that plays an important role in regulation of glucose and lipid metabolism. Adiponectin also has the properties of insulin sensitization, anti-inflammatory, angiogenic, and vasodilation that can affect central nervous system disorders (CNS).
Adiponectin entered the brain through peripheral circulation. In the brain, Adiponectin signifies through its receptors, Adipor1 and Adipip2, directly affecting important brain function such as energy homeostasis, hippocampal neurogenesis, and synaptic plasticity. You can get an in-depth knowledge of adiponectin ELISA at Boster Bio.
Overall, based on central and peripheral actions, the latest evidence shows that adiponectin has a neuroprotective, and antidepressant effect. However, these findings are not without controversy because human observational studies report different correlations between plasma adiponectin levels and CNS disorders.
Apart from this controversy, Adiponectin gets attention as a potential therapeutic target for various CNS disorders, such as strokes, Alzheimer's diseases, anxiety, and depression. Adiponectin ELISA quantitates Hu Adiponectin in human serum, plasma, urine, or cell culture media. Fast ELISA kits are available online.
The test will exclusively recognize natural and recombinant adats. Adiponnectin Solid-Phase Elisa Sandwich is designed to measure the number of targets bound between suitable antibody pairs. The target specific antibodies have been coated in the microplate well provided. Samples, standards, or controls are then added to this well and bind to the immobilized antibodies (capture).
This sandwich is formed by the addition of the second antibody (detector), the substrate solution is added that reacts with the complex target enzyme-antibody to produce a measurable signal. This signal intensity is directly proportional to the concentration of targets in the original specimen.
Each manufacturing lot of this elisa kit is a quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. Adiponectin is a protein hormone exclusively by adipocytes that regulate lipid and glucose metabolism. Adiponectin has been shown to play a role in various physiological processes including homeostasis and obesity.